The University Medical Center Göttingen (UMG) unites the Medical Faculty of the Georg-August University and the University Hospital in an integration model. With around 9,700 employees, the UMG and its subsidiaries are one of the largest employers in the region. Our clinics and institutes stand for high-quality patient care, excellent research, modern teaching and transfer of innovative technology.
Göttingen as a city of science is located in the center of Germany and the University Medical Center Göttingen is integrated into an attractive network of university and non-university scientific institutions.
The Institut für Herz- und Kreislaufphysiologie of the University Medical Center Göttingen is looking for a new position for the earliest start date
PhD student (f/m/d)
part time , 25 hours per week , limited for 3 years
65% TV-L E13, 3 years
Group of Prof. Dr. Ivan Bogeski, University Medical Center Göttingen, Germany
The University Medical Center Göttingen (UMG), is a leading institution in research, teaching, healthcare, and professional development. We are committed to patient-centered care, scientific excellence, international collaboration, and equal opportunity.
The research group of Prof. Dr. Ivan Bogeski is seeking a highly motivated PhD student to investigate the dynamics of ER-mitochondrial contact sites using state-of-the-art microscopy techniques. In collaboration with the group of Prof. Dr. Nadja Simeth-Crespi (Department of Chemistry), we aim to develop novel fluorescent tools to explore organellar signaling processes, including lipid transfer and calcium fluxes.
The project will involve the development, establishment, and optimization of fluorescently labeled small molecules, as well as live-cell imaging using advanced microscopy platforms (e.g., confocal, STED, sensor-based imaging). You will also apply molecular cloning and CRISPR/Cas9-mediated genome editing in well-established cancer cell models (melanoma and PDAC).
This is an exciting opportunity to work at the intersection of cell biology, chemical biology, and advanced imaging in a highly interdisciplinary and international team, within the structured PhD program GAUSS/GGNB.
Application:
Applications should include a cover letter, CV, certificates and names of two referees. Please upload your application as one PDF-file until 15.07.2025 to the online application system. We look forward to receiving your application! Please note that disabled people will be given preferential consideration in case of equal suitability. Travel and application fees cannot be refunded.
Bibliography:
- Redox signals at the ER-mitochondria interface control melanoma progression. EMBO J. 2019 Aug 1;38(15):e100871. doi: 10.15252/embj.2018100871.
- MCU controls melanoma progression through a redox-controlled phenotype switch. EMBO Rep. 2022 Nov 7;23(11):e54746. doi: 10.15252/embr.202254746.
- Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses. EMBO Rep. 2025 Jan;26(2):407-442. doi: 10.1038/s44319-024-00313-4.
